Download calculix 2 4-dinitrophenol

This page was last edited on 12 february 2016, at 20. We report the cases of two individuals, one in tacoma, wa, and the second in san diego, ca, whose deaths were attributed to ingestion of 2, 4 dinitrophenol 2, 4 dnp. Our evidencebased analysis on 2,4dinitrophenol features 23 unique references to scientific papers. Identification 2, 4 dinitrophenol is a yellow crystalline sandlike solid but is often found in a solution.

New highly selective method is suggested for synthesis of 2,4dinitrophenol by nitration of phenol with nitric acid in an aqueousalcoholic medium at the boiling point. A threedimensional structural finite element program. For additional information on the health effects of this chemical, interested parties are referred to the. Dnp 2,4dinitrophenol is a chemical product that was historically used as an antiseptic, herbicide, and explosive. Get a printable copy pdf file of the complete article 2. Full text full text is available as a scanned copy of the original print version. Personal protective equipment eyeface protection face shield and safety glasses use equipment for eye protection tested and approved under appropriate government standards such as niosh us or en 166eu. New highly selective method is suggested for synthesis of 2,4dinitrophenol by nitration of phenol with nitric acid in an aqueousalcoholic medium at the boiling point of the reaction mixture. It is a yellow, crystalline solid that has a sweet, musty odor.

Full text is available as a scanned copy of the original print version. Dnp is sold mostly over the internet under a number of different names as a weight lossslimming aid. Dnp by moving protons across the mitochondrial membrane breaks the process of oxidative phosphorylation, whereby there is an active waste of energy, but without the synthesis of adenosine triphosphate molecules. Associations of 2,4dinitrophenol with other chemical compounds. Dnp is used in developing photography, killing fungi, and as an industrial pesticide.

It is just of one of many newspapers and websites who have reported on the death of chris mapletoft, who died after taking 2,4dinitrophenol dnp. Analytical, diagnostic and therapeutic context of 2,4. Classified as an uncoupler of oxidative phosphorylation medically, it is quite. This page is regularly updated, to include the most recently available clinical trial evidence. The atsdr toxicological profile succinctly characterizes the toxicologic and adverse health effects information for the hazardous substance described here.

For the sake of clarity, ill use 2,4dnph throughout here. The chemical structure of 2,4dinitrophenol is shown in figure 1. Reason for citation 2,4dinitrophenol is on the hazardous substance list because it is cited by epa. It has an implicit and explicit solver ccx written by guido dhondt and a pre and postprocessor cgx written by klaus wittig. Using 2, 4 dnp as a shell filling was less sensitive than picric acid on its own. Uses the predominant use of 2,4dinitrotoluene is as an intermediate in the manufacture of polyurethanes. The html files must be downloaded directly or compiled from. In turn the pre processor is able to write mesh related data for nastran. If an internal link led you here, you may wish to change the link to point directly to the intended article. Other pertinent literature is also presented, but is described in less detail than the key studies. Here you find the text of the gnu general public license version 2. Warnings issued over deadly dnp diet drug thursday 19 september 20 tragedy of the gifted rugby player, 18, who died after buying deadly fatburning pills online, the daily mail reports.

Results obtained from calculix are in no way connected to abaqus. Once the intermediate is broken down, by other reactions, the coupling enzyme is prevented from reassociation with the electron transport particles by 2, 4 dinitrophenol. A threedimensional structural finite elemente program. Dinitrophenol for weight loss has been used for almost a hundred years, but was officially deprived of medical drug status in 1938 due to the high. Calculix is a package designed to solve field problems. Links to pubmed are also available for selected references. It has a role as an oxidative phosphorylation inhibitor, a bacterial xenobiotic metabolite and an antiseptic drug.

The mechanism of uncoupling of oxidative phosphorylation. Dnp is known by its official name, 2,4dinitrophenol, and is considered an industrial chemical. Youve probably seen 2,4dinitrophenylhydrazine referred to alternately as 2,4dnph or 2,4dnp. Reason for citation 2, 4 dinitrophenol is on the hazardous substance list because it is cited by epa. Contact information can be found at the bottom of the download page. A weight loss agent with significant acute toxicity and risk of death, however in studies of intermediateduration oral exposure to 2,4dnp, cases of death from agranulocytosis described in the discussion of hematological effects have been attributed to. Available downloads for the graphical interface calculix graphix. The mechanism of uncoupling of oxidative phosphorylation by 2. Our evidencebased analysis on 2, 4 dinitrophenol features 23 unique references to scientific papers. June 7, 2019 properties and mechanism of action dinitrophenols are a chemical group consisting of six different synthetic substances. Imagine a global collaborative knowledge base for original thoughts nature genetics. It is also used in the synthesis of coumarins and in the preparation of chloroformates as pharmaceutical reagents. Pdf two deaths attributed to the use of 2,4dinitrophenol. Files are available under licenses specified on their description page.

Dnp 2,4dinitrophenol, an industrial chemical with various applications, has gained steady popularity as a fat loss tool. Using 2,4dnp as a shell filling was less sensitive than picric acid on its own. The most important of these is 2,4, dinitrophenol, which is commonly called dnp. Each member of our research team is required to have no conflicts of interest, including with supplement manufacturers, food companies, and industry. Incompatible with heavy metals and their compounds. The chemical structure of 2, 4 dinitrophenol is shown in figure 1. First aid measures general advice consult a physician. However, 2,4dnp can also refer to 2,4dinitrophenol, which isnt the specific chemical being discussed in this. Nevertheless, an explosion in a munitions factory at rainham in essex in 1916 was attributed to 2, 4 dinitrophenol. The results from these studies, however, have shown a multiplicity of effects that suggest a more complicated interaction with the mtx transport system than adenosine 5. It is volatile with steam and is soluble in most organic solvents as well as aqueous alkaline solutions. Like t4, the drug stimulates metabolism by uncoupling oxidative phosphorylation in mitochondria. The lowest published lethal human oral dose of dnp is 4. Regular use of 2, 4dinitrophenol dnp is reported to cause rapid loss of weight, but unfortunately is associated with an unacceptably high rate of significant side effects 2.

Identification 2,4dinitrophenol is a yellow crystalline sandlike solid but is often found in a solution. Boasting an astounding 50% increase in metabolic rate, it is able to contribute to reported fat losses of 1012 pounds in 8 days of use. When in a dry form, it is a high explosive and has an instantaneous explosion hazard. A weight loss agent with significant acute toxicity and risk of death, however in studies of intermediateduration oral exposure to 2, 4 dnp, cases of death from agranulocytosis described in the discussion of hematological effects have been attributed to. Strictly speaking, the former is more correct, though the latter is commonly used to refer to it too. There is no compound on earth that can burn fat at the rate of dnp. This set index page lists chemical compounds articles associated with the same name.

Uses the predominant use of 2, 4 dinitrotoluene is as an intermediate in the manufacture of polyurethanes. Due credit and reputation for authors authorship tracking technology. Calculix is a free and opensource finiteelement analysis application that uses an input format similar to abaqus. The mechanism of uncoupling of oxidative phosphorylation by 2, 4dinitrophenol received for publication, january 18, 1967 gifford b. Like tnt, it was found to be toxic to the munition workers handling it. We report the cases of two individuals, one in tacoma, wa, and the second in san diego, ca, whose deaths were attributed to ingestion of 2,4dinitrophenol 2,4dnp. However, 2,4dnp can also refer to 2,4dinitrophenol, which isnt the specific chemical being discussed in this story. Dnp is a cytotoxin that turns off oxidative phosphorylation i. Calculix binaries for ms windows, made with cygwin and arpack.

In turn the preprocessor is able to write mesh related data for nastran. It has a role as a bacterial xenobiotic metabolite. Other applications include uses as an intermediate in dye processes and in smokeless gunpowders. Table of contents 1 history 2 how it works 3 bodybuilding 4 side effects 5. Use proper glove removal technique without touching gloves outer surface to avoid skin contact with this product. In bodybuilding, it is used for rapid fat loss, but its considered extremely dangerous when ingested. Show this safety data sheet to the doctor in attendance. The worlds first wiki where authorship really matters. Electronic spectrum of 2,4dinitrophenol in a 2 m solution of ammonia. The first death due to dnp c 6h 4n 2o 5 was reported in 1918 and was secondary to occupational exposure 3. Tragedy of the gifted rugby player, 18, who died after buying deadly fatburning pills online, the daily mail reports. The acute shortterm effects of 2,4dinitrophenol in humans through oral exposure are nausea, vomiting, sweating, dizziness, headaches, and loss of weight.

All structured data from the file and property namespaces is available under the creative commons cc0 license. So while it goes work well at burning fat, youre ingesting an industrial poison to do so, and that is no hyperbole. Safety data sheet northwest missouri state university. It is used in dyes, photo developers, explosives, and as a preservative of lumber.

Any one of six isomeric substituent products of benzene having the empirical formula 2c6h3oh explanation of 2,4dinitrophenol. Dnp 2, 4 dinitrophenol 100 mg capsules,anabolic steroids price list. Chemical compound and disease context of 2,4dinitrophenol. Structure, properties, spectra, suppliers and links for. What is 2,4dnph and why are schools carrying out controlled. Nevertheless, an explosion in a munitions factory at rainham in essex in 1916 was attributed to 2,4dinitrophenol. It sublimes, is volatile with steam, and is soluble in most organic solvents as well as aqueous alkaline solutions. Nov 16, 2012 new highly selective method is suggested for synthesis of 2, 4 dinitrophenol by nitration of phenol with nitric acid in an aqueousalcoholic medium at the boiling point of the reaction mixture. Chronic oral exposure to 2, 4 dinitrophenol in humans and animals has resulted in the formation of cataracts and skin lesions and has caused effects on the bone marrow, cns, and cardiovascular system. Dnp 2, 4 dinitrophenol is a chemical product that was historically used as an antiseptic, herbicide, and explosive. Also incompatible with strong oxidizing agents, strong bases and reducing agents. Sep 26, 2019 the atsdr toxicological profile succinctly characterizes the toxicologic and adverse health effects information for the hazardous substance described here.